Luurtsema, Gert: search on Z-Library

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1

Synthesis and evaluation of new fluorine-18 labeled verapamil analogs to investigate the function of P-glycoprotein in the blood-brain barrier

Raaphorst, Renske Maria, Luurtsema, Gert, Schuit, Robert C., Kooijman, Esther J.M., Elsinga, Philip H., Lammertsma, Adriaan A., Windhorst, Albert D.

Journal:

ACS Chemical Neuroscience

Year:

2017

Language:

english

File:

PDF, 1.47 MB

english, 2017

2

Synthesis and Preclinical Evaluation of Three Novel Fluorine-18 Labeled Radiopharmaceuticals for P-Glycoprotein PET Imaging at the Blood–Brain Barrier

Savolainen, Heli, Cantore, Mariangela, Colabufo, Nicola A., Elsinga, Philip H., Windhorst, Albert D., Luurtsema, Gert

Journal:

Molecular Pharmaceutics

Year:

2015

Language:

english

File:

PDF, 2.59 MB

english, 2015

3

Vascular uptake on 18F-sodium fluoride positron emission tomography: precursor of vascular calcification?

den Harder, Annemarie M., Wolterink, Jelmer M., Bartstra, Jonas W., Spiering, Wilko, Zwakenberg, Sabine R., Beulens, Joline W., Slart, Riemer H. J. A., Luurtsema, Gert, Mali, Willem P., de Jong, Pim A

Journal:

Journal of Nuclear Cardiology

Year:

2020

Language:

english

File:

PDF, 983 KB

english, 2020

4

The Role of P-Glycoprotein in Psychiatric Disorders: A Reliable Guard of the Brain?

L. de Klerk, Onno, J. Bosker, Fokko, Luurtsema, Gert, M. Nolte, Ilja, Dierckx, Rudi, A. den Boer, Johan, Potschka, Heidrun

Journal:

Central Nervous System Agents in Medicinal Chemistry(Formerly Current Medicinal Chemistry - Central Nervous System Agents)

Year:

2011

Language:

english

File:

PDF, 185 KB

english, 2011

5

Robotic synthesis of l-[1-11C]tyrosine

Gert Luurtsema, Jitze Medema, Philip H. Elsinga, Gerben M. Visser, Willem Vaalburg

Journal:

Applied Radiation and Isotopes

Year:

1994

Language:

english

File:

PDF, 673 KB

english, 1994

6

Pharmacoresistance in Epilepsy: A Pilot PET Study with the P-Glycoprotein Substrate R-[11C]verapamil

Oliver Langer, Martin Bauer, Alexander Hammers, Rudolf Karch, Ekaterina Pataraia, Matthias J. Koepp, Aiman Abrahim, Gert Luurtsema, Martin Brunner, Raute Sunder-Plassmann, Friedrich Zimprich, Christia

Journal:

Year:

2007

Language:

english

File:

PDF, 271 KB

english, 2007

7

Relationship of cerebrospinal fluid biomarkers with in vivo [11C]PIB and [18F]FDDNP binding

Bart N.M. van Berckel, Nelleke Tolboom, Wiesje M. van der Flier, Maqsood Yaqub, Ronald Boellaard, Nicolaas A. Verwey, Marinus A. Blankenstein, Gert Luurtsema, Albert D. Windhorst, Adriaan A. Lammertsm

Journal:

Alzheimer's & Dementia

Year:

2009

Language:

english

File:

PDF, 45 KB

english, 2009

8

Evaluation of (R)-[11C]verapamil as PET tracer of P-glycoprotein function in the blood–brain barrier: kinetics and metabolism in the rat

Gert Luurtsema, Carla F.M. Molthoff, Robert C. Schuit, Albert D. Windhorst, Adriaan A. Lammertsma, Eric J.F. Franssen

Journal:

Nuclear Medicine and Biology

Year:

2005

Language:

english

File:

PDF, 228 KB

english, 2005

9

IC-P3-224: Regional variations in age dependence of P-gp mediated transport across the blood-brain barrier measured using (R)-[11C]verapamil and positron emission tomography

Bart van Berckel, Mark Lubberink, Gert Luurtsema, Ronald Boellaard, Adriaan Lammertsma

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 114 KB

english, 2008

10

Evaluation of [ 18 F]MC225 as a PET radiotracer for measuring P-glycoprotein function at the blood–brain barrier in rats: Kinetics, metabolism, and selectivity

Savolainen, Heli, Windhorst, Albert D, Elsinga, Philip H, Cantore, Mariangela, Colabufo, Nicola A, Willemsen, Antoon TM, Luurtsema, Gert

Journal:

Journal of Cerebral Blood Flow and Metabolism

Year:

2016

Language:

english

File:

PDF, 682 KB

english, 2016

11

(R)-[11C]Verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

Stina Syvänen, Gert Luurtsema, Carla FM Molthoff, Albert D Windhorst, Marc C Huisman, Adriaan A Lammertsma, Rob A Voskuyl, Elizabeth C de Lange

Journal:

BMC Medical Imaging

Year:

2011

Language:

english

File:

PDF, 1.46 MB

english, 2011

12

New Molecular Targets for PET and SPECT Imaging in Neurodegenerative Diseases

Benadiba, Marcel, Luurtsema, Gert, Wichert-Ana, Lauro, Buchpigel, Carlos Alberto, Filho, Geraldo Busatto

Journal:

Revista Brasileira de Psiquiatria

Year:

2012

Language:

english

File:

PDF, 2.30 MB

english, 2012

13

In vivo and in vitro evidence that99mTc-HYNIC-interleukin-2 is able to detect T lymphocytes in vulnerable atherosclerotic plaques of the carotid artery

Glaudemans, Andor W. J. M., Bonanno, Elena, Galli, Filippo, Zeebregts, Clark J., de Vries, Erik F. J., Koole, Michel, Luurtsema, Gert, Boersma, Hendrikus H., Taurino, Maurizio, Slart, Riemer H. J. A.,

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Year:

2014

Language:

english

File:

PDF, 7.48 MB

english, 2014

14

Comparison of In Vitro Assays in Selecting Radiotracers for In Vivo P-Glycoprotein PET Imaging

Raaphorst, Renske, Savolainen, Heli, Cantore, Mariangela, van de Steeg, Evita, van Waarde, Aren, Colabufo, Nicola, Elsinga, Philip, Lammertsma, Adriaan, Windhorst, Albert, Luurtsema, Gert

Journal:

Pharmaceuticals

Year:

2017

Language:

english

File:

PDF, 5.91 MB

english, 2017

15

Fully automated high yield synthesis of (R)- and (S)-[11C]verapamil for measuring P-glycoprotein function with positron emission tomography

Gert Luurtsema, Albert D. Windhorst, Martien P.J. Mooijer, Jacobus D.M. Herscheid, Adriaan A. Lammertsma, Eric J.F. Franssen

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

2002

Language:

english

File:

PDF, 118 KB

english, 2002

16

An automated synthesis module for preparation of l-3-[123I]iodo-alpha-methyl tyrosine

Gert Luurtsema, Pieter L Jager, Albertus Piers, Marjolijn N de Hooge

Journal:

Applied Radiation and Isotopes

Year:

2001

Language:

english

File:

PDF, 112 KB

english, 2001

17

Evaluation of [11C]laniquidar as a tracer of P-glycoprotein: radiosynthesis and biodistribution in rats

Gert Luurtsema, Robert C. Schuit, Rob P. Klok, Joost Verbeek, Josée E. Leysen, Adriaan A. Lammertsma, Albert D. Windhorst

Journal:

Nuclear Medicine and Biology

Year:

2009

Language:

english

File:

PDF, 360 KB

english, 2009

18

Peripheral metabolism of [18F]FDDNP and cerebral uptake of its labelled metabolites

Gert Luurtsema, Robert C. Schuit, Kevin Takkenkamp, Mark Lubberink, N. Harry Hendrikse, Albert D. Windhorst, Carla F.M. Molthoff, Nelleke Tolboom, Bart N.M. van Berckel, Adriaan A. Lammertsma

Journal:

Nuclear Medicine and Biology

Year:

2008

Language:

english

File:

PDF, 369 KB

english, 2008

19

Feasibility of [18F]-RGD for ex vivo imaging of atherosclerosis in detection of αvβ3 integrin expression

Golestani, Reza, Mirfeizi, Leila, Zeebregts, Clark J., Westra, Johanna, de Haas, Hans J., Glaudemans, Andor W. J. M., Koole, Michel, Luurtsema, Gert, Tio, René A., Dierckx, Rudi A. J. O., Boersma, Hen

Journal:

Journal of Nuclear Cardiology

Year:

2015

Language:

english

File:

PDF, 578 KB

english, 2015

20

Microglia Activation in Recent-Onset Schizophrenia: A Quantitative (R)-[11C]PK11195 Positron Emission Tomography Study

Bart N. van Berckel, Matthijs G. Bossong, Ronald Boellaard, Reina Kloet, Alie Schuitemaker, Esther Caspers, Gert Luurtsema, Albert D. Windhorst, Wiepke Cahn, Adriaan A. Lammertsma, René S. Kahn

Journal:

Biological Psychiatry

Year:

2008

Language:

english

File:

PDF, 90 KB

english, 2008

21

Improving metabolic stability of fluorine-18 labeled verapamil analogs

Raaphorst, Renske M., Luurtsema, Gert, Schokker, Cindy J., Attia, Khaled A., Schuit, Robert C., Elsinga, Philip H., Lammertsma, Adriaan A., Windhorst, Albert D.

Journal:

Nuclear Medicine and Biology

Year:

2018

File:

PDF, 1000 KB

2018

22

Test-retest variability of quantitative [11C]PIB studies in Alzheimer’s disease

Nelleke Tolboom, Maqsood Yaqub, Ronald Boellaard, Gert Luurtsema, Albert D. Windhorst, Philip Scheltens, Adriaan A. Lammertsma, Bart N. M. van Berckel

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Year:

2009

Language:

english

File:

PDF, 261 KB

english, 2009

23

Evaluation of Basis Function and Linear Least Squares Methods for Generating Parametric Blood Flow Images Using15O-Water and Positron Emission Tomography

Ronald Boellaard, Paul Knaapen, Abraham Rijbroek, Gert J. J. Luurtsema, Adriaan A. Lammertsma

Journal:

Molecular Imaging and Biology

Year:

2005

Language:

english

File:

PDF, 644 KB

english, 2005

24

Erratum to: Dose-dependent sigma-1 receptor occupancy by donepezil in rat brain can be assessed with11C-SA4503 and microPET

Ramakrishnan, Nisha K., Visser, Anniek K. D., Schepers, Marianne, Luurtsema, Gert, Nyakas, Csaba J., Elsinga, Philip H., Ishiwata, Kiichi, Dierckx, Rudi A. J. O., van Waarde, Aren

Journal:

Psychopharmacology

Year:

2014

Language:

english

File:

PDF, 78 KB

english, 2014

25

Metabolism of (R)-[11C]verapamil in epilepsy patients

Aiman Abrahim, Gert Luurtsema, Martin Bauer, Rudolf Karch, Christoph Baumgartner, Kurt Kletter, Markus Müller, Oliver Langer

Journal:

BMC Pharmacology

Year:

2007

Language:

english

File:

PDF, 81 KB

english, 2007

26

Optimization of parathyroid 11C-choline PET protocol for localization of parathyroid adenomas in patients with primary hyperparathyroidism

Noltes, Milou E., Kruijff, Schelto, Noordzij, Walter, Telenga, Eef D., Vállez García, David, Trofimiuk-Müldner, Malgorzata, Opalińska, Marta, Hubalewska-Dydejczyk, Alicja, Luurtsema, Gert, Dierckx, Ru

Journal:

EJNMMI Research

Year:

2019

Language:

english

File:

PDF, 873 KB

english, 2019

27

PET imaging of αvβ3integrin expression in tumours with68Ga-labelled mono-, di- and tetrameric RGD peptides

Ingrid Dijkgraaf, Cheng-Bin Yim, Gerben M. Franssen, Robert C. Schuit, Gert Luurtsema, Shuang Liu, Wim J. G. Oyen, Otto C. Boerman

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Year:

2011

Language:

english

File:

PDF, 356 KB

english, 2011

28

Synthesis and preclinical evaluation of [11C]D617, a metabolite of (R)-[11C]verapamil

Joost Verbeek, Stina Syvänen, Robert C. Schuit, Jonas Eriksson, Elizabeth C. de Lange, Albert D. Windhorst, Gert Luurtsema, Adriaan A. Lammertsma

Journal:

Nuclear Medicine and Biology

Year:

2012

Language:

english

File:

PDF, 747 KB

english, 2012

29

SAR Studies on Tetrahydroisoquinoline Derivatives: The Role of Flexibility and Bioisosterism To Raise Potency and Selectivity toward P-glycoprotein

Capparelli, Elena, Zinzi, Laura, Cantore, Mariangela, Contino, Marialessandra, Perrone, Maria Grazia, Luurtsema, Gert, Berardi, Francesco, Perrone, Roberto, Colabufo, Nicola A.

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.97 MB

english, 2014

30

Cross-coupling of [ 11 C]methyllithium for 11 C-labeled PET tracer synthesis

Helbert, Hugo, Farinha Antunes, InÃªs, Luurtsema, Gert, Szymanski, Wiktor, Feringa, Ben L, Elsinga, Philip H.

Journal:

Chemical Communications

Year:

2020

File:

PDF, 1.26 MB

2020

31

Cutamesine Overcomes REM Sleep Deprivation-Induced Memory Loss: Relationship to Sigma-1 Receptor Occupancy

Ramakrishnan, Nisha K., Schepers, Marianne, Luurtsema, Gert, Nyakas, Csaba J., Elsinga, Philip H., Ishiwata, Kiichi, Dierckx, Rudi A. J. O., van Waarde, Aren

Journal:

Molecular Imaging and Biology

Year:

2015

Language:

english

File:

PDF, 547 KB

english, 2015

32

Peripheral metabolism of (R)-[11C]verapamil in epilepsy patients

Aiman Abrahim, Gert Luurtsema, Martin Bauer, Rudolf Karch, Mark Lubberink, Ekaterina Pataraia, Christian Joukhadar, Kurt Kletter, Adriaan A. Lammertsma, Christoph Baumgartner, Markus Müller, Oliver La

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Year:

2008

Language:

english

File:

PDF, 191 KB

english, 2008

33

P4-292: Regional variations in age dependence of P-gp–mediated transport across the blood-brain barrier measured using (R)-[11C]verapamil and PET

van Berckel, Bart N.M., Lubberink, Mark, Luurtsema, Gert, Boellaard, Rol, Lammertsma, Adriaan

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 63 KB

english, 2008

34

Development of [ 18 F]-Labeled Pyrazolo[4,3- e ]-1,2,4- triazolo[1,5- c ]pyrimidine (SCH442416) Analogs for the Imaging of Cerebral Adenosine A 2A Receptors with Positron Emission Tomography

Khanapur, Shivashankar, Paul, Soumen, Shah, Anup, Vatakuti, Suresh, Koole, Michel J. B., Zijlma, Rolf, Dierckx, Rudi A. J. O., Luurtsema, Gert, Garg, Prabha, van Waarde, Aren, Elsinga, Philip H.

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 6.58 MB

english, 2014

35

Editorial (Thematic Issue: Measurements of ABC Transporters at the Blood-Brain Barrier: Novel Methods and Applications)

Luurtsema, Gert

Journal:

Current Pharmaceutical Design

Year:

2016

Language:

english

File:

PDF, 307 KB

english, 2016

36

P-glycoprotein Function in the Rodent Brain Displays a Daily Rhythm, a QuantitativeIn VivoPET Study

Savolainen, Heli, Meerlo, Peter, Elsinga, Philip H., Windhorst, Albert D., Dierckx, Rudi A.J.O., Colabufo, Nicola A., van Waarde, Aren, Luurtsema, Gert

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 913 KB

english, 2016

37

Simplified parametric methods for [11C]PIB studies

Maqsood Yaqub, Nelleke Tolboom, Ronald Boellaard, Bart N.M. van Berckel, Erica W. van Tilburg, Gert Luurtsema, Philip Scheltens, Adriaan A. Lammertsma

Journal:

Year:

2008

Language:

english

File:

PDF, 869 KB

english, 2008

38

Potential Therapeutic Applications of Adenosine A 2A Receptor Ligands and Opportunities for A 2A Receptor Imaging

van Waarde, Aren, Dierckx, Rudi A. J. O., Zhou, Xiaoyun, Khanapur, Shivashankar, Tsukada, Hideo, Ishiwata, Kiichi, Luurtsema, Gert, de Vries, Erik F. J., Elsinga, Philip H.

Journal:

Medicinal Research Reviews

Year:

2017

Language:

english

File:

PDF, 722 KB

english, 2017

39

Optimizing an online SPE–HPLC method for analysis of (R)-[11C]1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide [(R)-[11C]PK11195] and its metabolites in humans

Henri N.J.M. Greuter, Patricia L.B. van Ophemert, Gert Luurtsema, Bart N.M. van Berckel, Eric J.F. Franssen, Bert D. Windhorst, Adriaan A. Lammertsma

Journal:

Nuclear Medicine and Biology

Year:

2005

Language:

english

File:

PDF, 118 KB

english, 2005

40

Focused ultrasound for opening blood-brain barrier and drug delivery monitored with positron emission tomography

Arif, Wejdan M., Elsinga, Philip H., Gasca-Salas, Carmen, Versluis, Michel, MartÃnez-FernÃ¡ndez, Raul, Dierckx, Rudi A.J.O., Borra, Ronald J.H., Luurtsema, Gert

Journal:

Journal of Controlled Release

Year:

2020

File:

PDF, 1.60 MB

2020

41

Evaluation of tracer kinetic models for quantification of P-glycoprotein function using (R)-[11C]verapamil and PET

Lubberink, Mark, Luurtsema, Gert, van Berckel, Bart N M, Boellaard, Ronald, Toornvliet, Rolf, Windhorst, Albert D, Franssen, Eric J F, Lammertsma, Adriaan A

Journal:

Journal of Cerebral Blood Flow and Metabolism

Year:

2006

Language:

english

File:

PDF, 269 KB

english, 2006

42

Transport across the blood-brain barrier: stereoselectivity and PET-tracers

Gert Luurtsema, Elizabeth C.M. de Lange, Adriaan A. Lammertsma, Eric J.F. Franssen

Journal:

Molecular Imaging and Biology

Year:

2004

Language:

english

File:

PDF, 414 KB

english, 2004

43

Dose-dependent sigma-1 receptor occupancy by donepezil in rat brain can be assessed with11C-SA4503 and microPET

Ramakrishnan, Nisha K., Visser, Anniek K. D., Schepers, Marianne, Luurtsema, Gert, Nyakas, Csaba J., Elsinga, Philip H., Ishiwata, Kiichi, Dierckx, Rudi A. J. O., van Waarde, Aren

Journal:

Psychopharmacology

Year:

2014

Language:

english

File:

PDF, 1.10 MB

english, 2014

44

Application of Liquid Chromatography combined with Mass-Spectrometry (LC-MS) to establish identity and purity of PET-radiopharmaceuticals

Eric J.F. Franssen, Gert Luurtsema, Jitze Medema, Gerben M. Visser, C.Margot Jeronismus-Shalingh, Andries P. Bruins, Willem Vaalburg

Journal:

Applied Radiation and Isotopes

Year:

1994

Language:

english

File:

PDF, 318 KB

english, 1994

45

Day-to-Day Test–Retest Variability of CBF, CMRO2, and OEF Measurements Using Dynamic15O PET Studies

Jochem P. Bremmer, Bart N. M. van Berckel, Suzanne Persoon, L. Jaap Kappelle, Adriaan A. Lammertsma, Reina Kloet, Gert Luurtsema, Abraham Rijbroek, Catharina J. M. Klijn, Ronald Boellaard

Journal:

Molecular Imaging and Biology

Year:

2011

Language:

english

File:

PDF, 497 KB

english, 2011

46

Detection of Intra-Abdominal Testicles with 16β-[18F]-Fluoro-5α-Dihydrotestosterone Positron Emission Tomography/Computed Tomography in a Pubertal Boy

Glaudemans, Andor W.J.M., de Vries, Erik F.J., Luurtsema, Gert, Cornelissen, E.A. Marlies, Feitz, Wout F., Farinha Antunes, Inês, Slart, Riemer H.J.A., Bongaerts, Alphons H.H., Kömhoff, Martin

Journal:

The Journal of Pediatrics

Year:

2015

Language:

english

File:

PDF, 320 KB

english, 2015

47

Carbon-11 Labeled Tracers for In Vivo Imaging of P-Glycoprotein Function: Kinetics, Advantages and Disadvantages

Luurtsema, Gert, Verbeek, Joost, Lubberink, Mark, A. Lammertsma, Adriaan, Dierckx, Rudi, Elsinga, Philip, D. Windhorst, Albert, van Waarde, Aren

Journal:

Current Topics in Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 408 KB

english, 2010

48

99mTc-HYNIC-IL-2 scintigraphy to detect acute rejection in lung transplantation patients: a proof-of-concept study

Telenga, Eef D., van der Bij, Wim, de Vries, Erik F. J., Verschuuren, Erik A. M., Timens, Wim, Luurtsema, Gert, Slart, Riemer H. J. A., Signore, Alberto, Glaudemans, Andor W. J. M.

Journal:

EJNMMI Research

Year:

2019

Language:

english

File:

PDF, 2.51 MB

english, 2019

49

Development of a tracer kinetic plasma input model for (R)-[11C]PK11195 brain studies

Kropholler, Marc A, Boellaard, Ronald, Schuitemaker, Alie, van Berckel, Bart N M, Luurtsema, Gert, Windhorst, Albert D, Lammertsma, Adriaan A

Journal:

Journal of Cerebral Blood Flow and Metabolism

Year:

2005

Language:

english

File:

PDF, 195 KB

english, 2005

50

IC-03-01: Imaging Alzheimer pathology in vivo: Quantitative comparison of [11C]PIB and [18F]FDDNP

Nelleke Tolboom, Maqsood Yaqub, Wiesje M. Van der Flier, Ronald Boellaard, Gert Luurtsema, Albert D. Windhorst, Frederik Barkhof, Philip Scheltens, Adriaan A. Lammertsma, Bart N.M. Van Berckel

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 59 KB

english, 2008

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